Immunogenicity of HIV virus-like particles in rhesus macaques by intranasal administration.
نویسندگان
چکیده
Female rhesus macaques were immunized with HIV virus-like particles (HIV-VLPs) or HIV DNA administered as sequential combinations of mucosal (intranasal) and systemic (intramuscular) routes, according to homologous or heterologous prime-boost schedules. The results show that in rhesus macaques only the sequential intranasal and intramuscular administration of HIV-VLPs, and not the intranasal alone, is able to elicit humoral immune response at the systemic as well as the vaginal level.
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ورودعنوان ژورنال:
- Clinical and vaccine immunology : CVI
دوره 19 6 شماره
صفحات -
تاریخ انتشار 2012